M'magawo a biopharmaceuticals ndi kafukufuku wasayansi, kuchotsa zosungunulira ndi kuyika kwazinthu ndizofunikira kwambiri pakuyesa komanso kupanga. Njira zachikhalidwe monga evaporation ndi centrifugation nthawi zambiri zimakhala zovuta, kutaya zinthu zogwira ntchito, komanso kuchotsa zosungunulira zosakwanira. Zowumitsira mu labotale, zokhala ndi maubwino apadera a kutentha kochepa komanso kutsika kwapang'onopang'ono, zatuluka ngati zida zothandiza kwambiri panjirazi. Mwa iwo,"BOTH" zowumitsa amaundanaali patsogolo pakupititsa patsogolo lusoli.
Sayansi Pambuyo Powumitsa Kuzizira: Kuchepa kwa Kutentha Kwambiri
A labotale amaundana chowumitsiraamakwaniritsa kuchotsa zosungunulira ndi ndende zinthu kudzera mu magawo atatu:
Gawo Lozizira Kwambiri:Zinthu zomwe zimakhala ndi zosungunulira zimawumitsidwa mwachangu pa kutentha kuyambira -40 ° C mpaka -80 ° C, kupanga makristasi olimba a ayezi.
Kuyanika Kwambiri (Sublimation):Pansi pa malo opanda mpweya (nthawi zambiri pansi pa 10Pa), makhiristo oundana amatsika mwachindunji kukhala nthunzi yamadzi, ndikuchotsa zosungunulira zoposa 90%.
Kuyanikanso Sekondale (Desorption):Kutentha pang'ono (20-40 ° C) kumathandizira kusungunuka kwathunthu kwa madzi omangika, zomwe zimapangitsa kuti pakhale chinyezi chomaliza cha 1% -5%.
Izi zimachotsa kuwonongeka kwa kutentha kwambiri kwa zinthu zomwe sizimva kutentha, kusunga mamolekyu a mapuloteni, ma enzyme, ndi mavitamini. Kuonjezera apo, imapanga porous porous yomwe imathandizira kuchepetsa madzi m'thupi mosavuta kapena kugwiritsa ntchito mwachindunji.
Ubwino Waikulu wa Zowumitsa Zowumitsa mu Laboratory
Poyerekeza ndi zida zamafakitale, zowumitsira ma labotale zimapatsa kuwongolera bwino kwambiri komanso mapindu ang'onoang'ono pokonza:
Kuwongolera Kutentha Kwambiri:Mtundu wa "BOTH" wowumitsa amawumitsaZLGJ-12mwachitsanzo, amagwiritsa ntchito ukadaulo woziziritsa wa kompresa wochokera kunja, kufikira kutentha kwa msampha motsika kwambiri -80°C kuti azitha kuzizira kwambiri.
Intelligent Vacuum Management:Masensa olondola kwambiri amawunika mosalekeza kuchuluka kwa vacuum (≤5Pa), okhala ndi njira zodzitchinjiriza zomwe zimateteza kusungirako zosungunulira.
Kutentha kwa Gradient kwa Concentration:Zokhala ndi ukadaulo wowongolera mashelufu (monga ukadaulo wa "BOTH" freeze dryer PLD control), makinawa amalola ma curve osakanikirana azinthu zosiyanasiyana, kukhathamiritsa ndende.
Mwachitsanzo, pakuyesa kwa labotale yokhudzana ndi kuzizira kwa ma antibody, njira zachikhalidwe zakusintha kwa nthunzi zidapangitsa kuti mapuloteni asanjike ndikutsekeka. Mosiyana ndi zimenezi, kuumitsa kozizira pa kutentha kochepa kumasungidwa pa 95% ya zochita za antibody, ndi ufa wotsatira umakhala wokhazikika kuti usungidwe kwa nthawi yaitali.
Monga kampani yomwe imagwira ntchito pazida zowumitsa zowuma m'nyumba kwa zaka 17, zowumitsira "BOTH" zowumitsa zoziziritsa kukhosi zathandizira kuchotsa zosungunulira pogwiritsa ntchito luso laukadaulo lopitilirabe.
1. Njira Yathunthu Yotsatirira Data
Chowumitsa chowumitsa cha labotale cha "BOTH" chili ndi chotchingira chamtundu komanso gawo losungiramo data (lotha kusunga ma rekodi 100,000). Amapereka nthawi yeniyeni kutentha-vacuum curves, zomwe zimathandiza ochita kafukufuku kudziwa bwino mapeto a zosungunulira zosungunulira, kuteteza kuyanika mopitirira muyeso kapena zotsalira zosungunulira.
2. Njira Zambiri Zotetezera Chitetezo
Kutsekera kwa pampu ya vacuum yodziwikiratu ngati kutentha kwa msampha kuli pamwamba pa -50 ° C kuteteza kuwonongeka kwa kubwerera.
Ma alamu omveka ndi opepuka okhala ndi chitetezo chodzidzimutsa ngati vacuum yalephera kapena kusinthasintha kwa kutentha.
Mphamvu yamagetsi ya UPS yosankha imasunga magwiridwe antchito kwa mphindi 20 panthawi yamagetsi, kuwonetsetsa kuti kuyesa kupitilira.
3. Modular Ntchito Kukula
Ndi njira yodzipangira yokhayokha yojambulira gasi, mipweya ya inert monga nayitrogeni imatha kulowetsedwa m'chipinda chowumitsira kuti mupewe kuyanika kwa okosijeni panthawi ya zosungunulira zomwe zimakhudzidwa ndi okosijeni (mwachitsanzo, ethanol). Chipindacho, chopangidwa ndi chitsulo chosapanga dzimbiri chaukhondo chokhala ndi msampha wopanda koyilo, chimachotsa ziwopsezo zopatsirana.
Zowumitsira mu labotale zowumitsira zasintha kuchokera ku zida zosavuta zochepetsera madzi m'thupi kukhala nsanja zapamwamba zowongolera. "ZOBWINO"Zithunzi za ZLGJmndandanda, kudzera mu kamangidwe kake kanzeru komanso kosinthika, sikuti kumangowonjezera kuchotseratu zosungunulira komanso kumathandizira kuyang'anira nthawi yeniyeni ndi kukhathamiritsa kwa ndende. Kwa ofufuza omwe amaika patsogolo kulondola koyesera ndi zotsatira zokhazikika, zida izi zikukhala "zothandizira" zokhazikika m'ma laboratories.
Nthawi yotumiza: Mar-13-2025
